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ensHS ens Amiloride-sensitive sodium channel delta-subunit (Epithelial Na+ ENSP00000305976 ENSG00000170145 ensHS ens salt-inducible kinase 2. ens Ileal sodium/bile acid cotransporter (Ileal Na(+)/bile acid cotransporter) (Na+ Sodium as salt and Potassium expert: Antti Jula, Finland. Peer reviewer: and fatty acids, which together with bile salts, lysophospholipids, and un- absorbed by facilitated diffusion that does not involve sodium co-transport. (GLUT 5). Intestinal sodium/glucose cotransporter 3 expression is epithelial and reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in. Lägga till sterila PEG 8000 i fosfatbuffrad saltlösning (PBS) insamlade medellång till en Kinetics of the bile acid transporter and hepatitis B virus receptor Na+/taurocholate cotransporting polypeptide (NTCP) in hepatocytes.
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These associations have suggested the hy-pothesis that alterations in either specific bile salt re-ceptors or membranelipid composition are important determinants of maximum bile salt transport. How-ever, these correlations have 2017-04-20 2006-09-01 Functional Expression Cloning and Characterization of the Hepatocyte Na^+/Bile Acid Cotransport System The system operates by a sodium ion cotransport mechanism, and it functions in maintaining a normal enterohepatic circulation of bile salts. Analysis of structure-activity data allows us to depict our hypothesis for the interaction of the bile salt and Na with the membranal recognition site of this transport … 1991-12-01 2004-12-01 Figure 1. Bile salt transporters in human liver and intestine. At the basolateral hepatocyte membrane, the major uptake system for con-jugated bile salts is the Na -dependent bile salt transporter NTCP (SLC10A1).
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It is strictly dependent on the extracellular presence of sodium. bile acid and bile salt transport Source: GO_Central "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium." Gaudet P. , Livstone M.S. , Lewis S.E. , Thomas P.D. Brief Bioinform 12:449-462(2011) [ PubMed ] [ Europe PMC ] [ Abstract ] The Na + taurocholate co-transporter (NTCP, SLC10A1) at the basolateral membrane of hepatocytes mediates bile salt (BS) uptake, whereas Na +-independent organic anion transporting polypeptides (OATPs) transport not only bile salts but also various organic anions (OA).
Na BS− Fig. 2. Bile salt carriers in rat and human hepatocytes, cholangiocytes, renal tubular cells and enterocytes. At the basolateral membrane, the Na+–taurocholate cotransporting polypeptides Ntcp (rat) and NTCP (human) mediate uptake of conjugated bile salts (BS−). In rat liver, Na+- 2002-01-01 The Bulletin, MDI Biological Laboratory V. 52, 2013 20 Characterization of a bile salt transport system in isolated hepatocytes from adult sea lamprey (Petromyzon marinus) Shi-Ying Cai1, Alison Pierik2 and James L. Boyer1,2 1 Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 2 Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672 2008-03-28 The Bulletin, MDI Biological Laboratory V. 53, 2014 4 Characterization of a bile salt transport system in isolated hepatocytes from adult sea lamprey (Petromyzon marinus) Shi-Ying Cai1, Daniël A. Lionarons1, and James L. Boyer1,2 1 Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 2 Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672 Although less is known about bile salt transport in the kidney, bile salts that escape ﬁrst-pass clearance by the liver after reabsorption from the intestine are ﬁltered at the glomerulus, where they are thought to be reabsorbed by a sodium-dependent bile salt transport mechanism in the proximal convoluted tubule.18–20 Thus, under nor-mal conditions, bile salt losses in urine are minimal.
The Na+-taurocholate cotransporting polypeptide (NTCP, SLC10A1) is a liver specific bile salt transporter
1991-12-01 · Burckhardt G, Kramer W, Kurz G, Wilson FA. Photoaffinity labeling studies of the rat renal sodium bile salt cotransport system. Biochem Biophys Res Commun. 1987 Mar 30; 143 (3):1018–1023. [Google Scholar] Wilson FA. Modern approaches to bile acid transport proteins.
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The pre-S1 domain of the large HBsAg protein promotes attachment and entry of HBV into the hepatocyte via liver cell–specific receptor recently identified as Na (sodium) taurocholate cotransporting polypeptide (NTCP), which is an integral membrane protein used in bile acid transport. 23,24 There is evidence that hepatocyte entry may be a multistep process including binding to heparan sulfate ASBT is Na-dependent uptake transporter of bile acids and conjugates. It has an important physiological function as the first step in bile acid (BA) reabsorption from the intestine, playing a key role in the enterohepatic recirculation of BAs . Although ASBT is expressed in other organs, its functions there are largely unexplored.
We characterized expression and activity of the bile salt transporters Na(+)/taurocholate (TC) cotransporting polypeptide (Ntcp), and bile salt export pump (Bsep), and the expression of organic anion transporting polypeptides 1 and 2 (Oatp1 and 2) and multidrug resistance associated protein-2 (Mrp2) in pregnancy and throughout lactation in rats.
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In contrast, recent expression studies in mammalian cell lines have suggested that the cloned rat liver Na(+)-taurocholate cotransporting polypeptide (Ntcp) may transport only taurocholate. 1 ways to abbreviate Na(+)-bile Salt Co-transporter. How to abbreviate Na(+)-bile Salt Co-transporter? Get the most popular abbreviation for Na(+)-bile Salt Co-transporter updated in 2021 1992-08-01 The Na+/bile salt co-transporter of the pig ileal brush border membrane has been expressed in Xenopus laevis oocytes. Injection of pig ileal poly (A)+ RNA into oocytes resulted in the functional expression of an Na(+)-gradient-stimulated taurocholate uptake within 2-5 days. The expressed Na(+)-dependent taurocholate uptake exhibited saturation kinetics (apparent Km 2021-04-01 bile acid moieties (GI and G2) are tethered together via a spacer, X, and where one of the two bile acid moieties carries a photoactivatable group. These photoblockers specifically interact with the ileal Na '/ bile-salt-cotransport system as demonstrated by a concentration-dependent inhibition of … The bile salt pool undergoes an enterohepatic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSEP (ABCB11), the ileal Na + -dependent bile salt transporter ISBT (SLC10A2), and the hepatic sinusoidal Na + - taurocholate cotransporting polypeptide NTCP (SLC10A1).
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Hepatocellular bile salt uptake is mediated predominantly by the Na + -taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na + -independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and OATP-C (humans).
Hosp Pract (Off Ed) 1990 Apr 15; 25 (4):95–110. [Google Scholar] 1992-08-01 · The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. bile acid and bile salt transport Source: GO_Central "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium." Gaudet P. , Livstone M.S. , Lewis S.E. , Thomas P.D. Brief Bioinform 12:449-462(2011) [ PubMed ] [ Europe PMC ] [ Abstract ] The Na + taurocholate co-transporter (NTCP, SLC10A1) at the basolateral membrane of hepatocytes mediates bile salt (BS) uptake, whereas Na +-independent organic anion transporting polypeptides (OATPs) transport not only bile salts but also various organic anions (OA).